After devoted service, Cardinal Wolsey (Jonathan Pryce, below, right) was cast off because he had failed to obtain an annulment for Henry from the Pope; Thomas More (Anton Lesser) was beheaded for his uncompromising opposition to reformation. Cromwell was to lose his own head over similar inconvenience to Henry, but that part of the story will take place in a sequel, if one follows.
Mark Rylance,shown below), a commoner who ran away from violence at home in his teens to soldier in Europe, learn banking in Italy and the law in London, later to become a steely survivor and fixer for Henry. He appears up close as a doting father and husband while back stage he stealthily orchestrates the machinations required to satisfy Henry's demands and fill his coffers. To those ends Cromwell first collaborated with Anne (Claire Foy) to contrive her succession to Katherine (Joanne Whalley) and then turned face rapidly, framing courtiers as Anne's lovers in order to depose her. Further, he conducted anti-Catholic purges, disposing of Catholic clerics, institutions, libraries -- depredations as ugly as present day terrorist destruction of Middle-Eastern ancient structures and relics.
(here) the two figures despite his own predispositions.
This clip (click the link) gives you a flavor of the interactions among the players as Anne begins to sense her control over her position is at risk.